School of Medicine

Wayne State University School of Medicine

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Abdul B. Abou-Samra, M.D., Ph.D.
Professor, Division Chief and Director of the Endocrinology Training Program
University Health Center - 4H
4201 St. Antoine
Detroit, MI 48201
313-745-4008
asamra@med.wayne.edu
Biography

Education:

  • M.D., Aleppo's University 1979
  • Ph.D. (Doctorat d' Etat), Biochemistry, Lyon 1 University 1983

Academic Positions and Hospital Employment:

  • 1979-1984 - Resident and Fellow, Internal Medicine and Endocrinology, Hôpital de l’ Antiquaille, Lyon, France /  Université Claude Bernard (Lyon I) Medical School, Lyon France.
  • 1984-1986 - Visiting Fellow, Endocrinology and Reproductive Research Branch, NICHD, NIH, Bethesda, Maryland.
  • 1986-1988 - Fellow in Endocrinology, Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston MA
  • 1988-2007 - Staff Physician, Massachusetts General Hospital, Boston, MA
  • 1986-1988 - Instructor in Medicine, Harvard Medical School, Boston, MA
  • 1988-1993 - Assistant Professor of Medicine, Harvard Medical School, Boston, MA
  • 1993-2007 - Associate Professor of Medicine, Harvard Medical School, Boston, MA
  • 2007-            Chief, Endocrinology, Diabetes and Metabolic Diseases, Wayne State University, Detroit, MI
  • 2007-            Director, Fellowship Program, Endocrinology, Diabetes and Metabolic Diseases
  • 2007 -           Professor of Medicine, Wayne State University, Detroit, MI
  • 2008-            Professor of Molecular Medicine and Genetics, Wayne State University, Detroit, MI
  • 2010-            Professor of Physiology, Wayne State University, Detroit, MI

Honors:

  • 1983 - Research Award, “Foundaton la Recherch Medicale”, Paris, France, 1984
  • 1984 - Maitre-Es-Science Medical, Lyon I University, Lyon France
  • 1994-2002 - Subcommittee of Study of Research Proposals, Mass General Hospital, Boston, MA
  • 2001 - Partners of Excellence Award
  • 2001-2003 - Endocrinology Study Section Center of Scientific Review, NIH
  • 2001-2004 - Editorial Board, Endocrinology
  • 2011  Board of governors faculty recognition award, Wayne State University.
  • 2012  Teaching award, Wayne State University School of Medicine
Joint Appointments
Center of Molecular Medicine and Genetics, Department of Physiology, Karmanos Cancer Institute
Research

Ongoing Research Support:

  • Principal Investigator,  R01 DK063211  (NIH/NIDDK) 1/15/03 - 12/31/11
    Role of PTH1R in bone biology using a phosphorylation-deficient PTH1R knock-in mouse model The goal of this project is to study the role of the phosphorylation of the PTH/PTHrP receptor in the physiological actions of PTH in vivo using a knock-in mouse model expressing a PTH1R in which the phosphorylation sites were mutated.
  • Principal Investigator, T32DK080657 (NIH/NIDDK) 7/1/2010 - 6/30/2015.  Training Program in Endocrinology and Diabetes. To provide postdoctoral endocrine research training to MDs who completed residency training in internal medicine and clinical fellowship in endocrinology.
  • Co-Investigator,1R56DK87848-01A1 (NIH/NIDDK) 7/1/2010 - 6/30/2011.   Role of MKP-1 in the anabolic actions of PTH in osteoblasts (PI: Nabanita Datta)

Previous Research Support (completed projects):

  • Principal Investigator,  R01 DK063211-01A1 (NIH/NIDDK)  7/1/2003 - 10/31/2008
    Bi-molecular interactions of the CRF ligands and receptors
    The goal of this project is to study the interactions between corticotropin-releasing factor (CRF), urocortin-1 and sauvagine with the CRF receptors.
  • Principal Investigator, SubProject II of P01 DK11794 (Potts, Program Director) 12/1/1993-11/30/2008
    Subproject II: "Regulation of the PTH/PTHrP receptor" of Program Project "Hormonal Control of Calcium Metabolism"
    The goals of this project are to characterize the post-translational mechanisms of desensitization and internalization of the PTH/PTHrP receptor.
  • Principal Investigator, R01DK045485 (NIH/NIDDK)   3/1/1995 - 2/29/2000
    Structure and Regulation of the PTH/PTHRP Receptor Gene
    The goals of this project are to clone and characterize the transcriptional regulation of the PTH/PTHrP receptor gene.
  • Principal Investigator, 5R01DK011794 (NIH/NIDDK) 1/1/1990 - 12/31/1995
    CRF Receptors- Structure, Function Expression
    The goals of this project are to clone the receptors for corticotropin releasing factor (CRF) and characterize its binding and signaling properties.
Peer-Reviewed Publications
Reviews and Books
  1. Abou-Samra AB, Fevre-Montange M, Borson F, Dechaud H, Tourniaire J. Circadian variation of immunoreactiveCRF in rat hypothalamus. In: Moody TW, ed. Neural and Endocrine Peptides and Receptors '85. New York: Plenum Press, 1986:149-157.
  2. Abou-Samra AB, Harwood JP, Catt KJ, Aguilera G. Mechanisms of action of CRF and other regulators of ACTH release. Ann NY Acad Sci. 1987; 512:67-86.
  3. Potts JT Jr, Nussbaum SR, Wiren K, Freeman M, Igarashi T, Okazaki T, Zajac J, Abou-Samra AB, Bringhurst FR, Segre GV, Kronenberg HM. Chemistry, molecular biology and mode of action of parathyroid hormone. In: Massery SG, Fujita T, eds. First International Conference on New Actions of Parathyroid Hormone, Kobe, Japan, October 26-31, 1987. New York: Plenum Press, 1989: 11-18.
  4. Segre GV, Abou-Samra AB, Jüppner H, Schipani E, Force T, Urena P, Freeman M, Kong XF, Kolakowski LF Jr, Hock J, Bonventre J, Potts JT Jr, Kronenberg HM. Characterization of cloned PTH/PTHrP receptors. J. Endocrinol. Invest. 1992, 15(supplement 6 to no. 9):11-17.
  5. Segre GV, Abou-Samra AB, Gardella TJ, Jüppner H, Kronenberg HM, Nussbaum SR, Potts JT Jr. Structural analysis of the PTH/PTHrP receptor's functional domains. In: Calcium Regulating Hormones and Bone Metabolism. Amsterdam: Elsevier Science Publishers BV, pp92-96.
  6. Kronenberg HM, Jüppner H, Abou-Samra AB, Potts JT, Jr, Segre GV. A common receptor for parathyroid hormone and parathyroid hormone-like peptide. In: Mornex R, Jaffiol C, Leclere J, eds. Proceedings of the Ninth International Congress on Endocrinology, Nice, France, 30 August-5 September 1992. Camforth, Lancs, UK: Parthenon Publishing, 1993:357-359.
  7. Abou-Samra AB, Juppner H, Kong XF, Schipani E, Iida-Klein A, Karga H, Urenea P, Gardella TF, Potts Jr JT, Kronenberg HM, Segre GV. Structure, fonction et expression de l’hormone parathyroidienne et du peptide apparenté à l’homone parathyroidienne. Actualite Nephrlogic Jean Hamburger, Hopital Necker 1993, pp185-201.
  8. Kronenberg HM, Bringhurst FR, Nussbaum SR, Jüppner H, Abou-Samra AB, Segre GV, Potts JT Jr. Parathyroid hormone: biosynthesis, secretion, chemistry, and action. In: Mundy GR, Martin TJ, eds. Handbook of Experimental Pharmacology (volume 107, 1993): Physiology and Pharmacology of Bone. Heidelberg, Germany: Springer-Verlag, pp507-567.
  9. Urena P, Abou-Samra AB, Juppner H, Kong XF, Lee K, Bringhaurst FR, Potts JTJr, Kronenberg HM, Segre GV. Mode d’action de l’hormone parathyroidienne (PTH) et du peptide apparenté à la PTH (PTHrP) au niveau des organs cibles. Les Annales d’Endocrinology (Paris) 1994, 55: 556-565.
  10. Abou-Samra AB, Juppner H, Kong XF, Schipani E, Iida-Klein A, Karga H, Urenea P, Gardella TF, Potts Jr JT, Kronenberg HM, Segre GV. Structure, Function and expression of the parathyroid hormone/parathyroid hormone receptor. Adv Nephrol 1994, 23:247-264.
  11. Juppner H, Schippanin E, Segre GV, Abou-Samra AB, Gardella T. Structure function studies with recombinant PTH/PTHrP receptors. J Bone Min Met 1994, 12 (Suppl 1): S169-S174.
  12. Juppner H and Abou-Samra AB Molecular Cloning of Peptide Hormone Receptors. In Principle of Bone Biology. (Ed: JP Bilezikian, LG Raisz and GA Rodan) Academic Press, pp1149-1160.
  13. Kong XF, Urena P, Schipani E, Jüppner H, Kronenberg HM, Potts JT Jr, Segre GV, Abou-Samra AB. Preliminary characterization of rat genomic clones encoding the common receptor for parathyroid hormone and parathyroid hormone related peptide. In: Calcium Regulating Hormones and Bone Metabolism. Amsterdam: Elsevier Science Publishers BV, pp97-101 (1993).
  14. Jüppner H, Abou-Samra AB. Molecular cloning of peptide hormones and their receptors. In: Bilezikian JP RL, Rodan GA, ed. Principles of Bone Biology. San Diego: Academic Press, 1996:1149-1159.
  15. Kronenberg H, Abou-Samra A, Bringhurst F, Gardella T, Jüppner H, Segre G. The PTH/PTHrP receptor: One receptor for two ligands. In: Thakker R, ed. Genetics of Endocrine and Metabolic Disorders. London: Chapman & Hall, 1997:389-420.
  16. Abou-Samra AB Parathyroid Hormone and Its Receptors. In Advances in Organ Biology: Molecular and cellular biology of bone. (Ed: Moniz), 1998 (Volume 5A):161-185.
  17. Demay M, Jüppner H, Abou-Samra AB, Segre GV, Kronenberg HM. Parathyroid hormone biosynthesis and action: molecular analysis of the PTH gene and PTH/PTHrP receptor. In: Noda M, ed. Molecular and Cellular Biology of the Bone. San Diego, California: Academic Press,
  18. Kronenberg HM, Abou-Samra AB, Jüppner H, Potts JT Jr, Segre GV. Characterization of a receptor that binds both PTH and PTHrP. In: Calcium Regulating Hormones and Bone Metabolism. Amsterdam: Elsevier Science Publishers BV, pp79-82.
  19. Datta NS and Abou-Samra AB. PTH and PTHrP in osteoblast. Cell Signal. 2009, 8:1245-1254
  20. Goustin AS and Abou-Samra AB.  The thrifty gene encoding Ahsg/fetuin-A meets the insulin receptor.  Cell Signal. 2011, 23:980-990
  21. Al-Sofiani M, Abou-Samra AB, Mousa SA.  Vitamin D, parathyroid hormone and parathyroid hormone-related peptide interaction in diabetes mellitus.  J Clin Metab Diab 2012, in press.
Patents
  1. Abou-Samra AB, Juppner H, Kronenberg HM, Potts JT, Schipani E, Segre GV. DNA and vectors encoding the parathyroid hormone receptor, transformed cells, and recombinant protein. US PATENT #5494806 issued 2/27/1996
  2. Abou-Samra AB, Juppner H, Kronenberg HM, Potts JT, Schipani E, Segre GV. Parathyroid hormone receptor and DNA encoding same. US PATENT #5840853 issued 11/24/1998
  3. Abou-Samra AB, Juppner H, Kronenberg HM, Potts JT, Schipani E, Segre GV.. Parathyroid hormone receptor. US PATENT # 5886148 issued 3/23/1999
  4. Segre GV, Kronenberg HM, Abou-Samra AB, Juppner H, Potts JT, Schipani E. DNA encoding parathyroid hormone receptor. US PATENT #10267730 issued 11/7/2006
  5. Segre GV, Kronenberg HM, Abou-Samra AB, Juppner H, Potts JT, Schipani E. Parathyroid hormone receptor binding method. US PATENT #7150974 issued 12/19/2006